Abstract
Selective annulations of alkynes represent a powerful tool for constructing multicyclic scaffolds while installing desired substitution patterns with precision. Herein, we report a Rh-catalyzed unique annulation of indolyl oxopropanenitrile with hydroxy-alkynoates to access pyranoindole cyclic motifs, featuring enol oxygen as a rare chemoselective reactive terminal. The reaction proceeds via a five-membered oxy-rodacycle through C-H activation by a rhodium complex guided by enolic- and propargyloxy dual co-ordination to enable a regio- and stereoselective modular assembly.
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