Abstract
Magnesium alloys as biodegradable metal implants have received a lot of interest in biomedical applications. However, magnesium alloys have extremely high corrosion rates a in physiological environment, which have limited their application in the orthopedic field. In this study, calcium phosphate compounds (Ca–P) coating was prepared by arginine–glycine–aspartic acid–cysteine (RGDC) peptide-induced mineralization in 1.5 simulated body fluid (SBF) to improve the corrosion resistance and biocompatibility of the AZ31 magnesium alloys. The adhesion of Ca–P coating to the AZ31 substrates was evaluated by a scratch test. Corrosion resistance and cytocompatibility of the Ca–P coating were investigated. The results showed that the RGDC could effectively promote the nucleation and crystallization of the Ca–P coating and the Ca–P coating had poor adhesion to the AZ31 substrates. The corrosion resistance and biocompatibility of the biomimetic Ca–P coating Mg alloys were greatly improved compared with that of the uncoated sample.
Highlights
Traditional implant materials such as titanium and its alloys, steel, and cobalt–chromium alloys are extensively used in orthopedics [1]
The present study demonstrated that Ca–P coating was successfully prepared on the AZ31 with the use of RGDC by using a biomimetic method
The contact angle results indicated that RGDC and
Summary
Traditional implant materials such as titanium and its alloys, steel, and cobalt–chromium alloys are extensively used in orthopedics [1]. Methods for forming the Ca–P coating to improve the corrosion resistance of magnesium alloys, such as have been reported [16,17]. The biomimetic method has attracted several focuses because it can the solution used during the coating process is similar to human plasma to prepare safe, offerbiocompatible a simple, low-temperature, non-toxic, and non-line-of-sight process [18]. Many researchers have introduced some active molecules on the surface of magnesium alloys to promote mineralization of Ca–P coatings. This hybrid coating can effectively improve the corrosion resistance of Mg alloys. Secchi et al [25] confirmed that arginyl-glycyl-aspartyl-serine (RGDS) peptides immobilized on the (RGDS) peptides immobilized on the titanium alloy stimulated bone cell differentiation. The corrosion resistance and of Ca–P coating on magnesium alloy in 1.5 simulated body fluid (SBF).
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