Abstract
Here we describe a case of Reye syndrome diagnosed at postmortem liver biopsy of a three-year old girl who presented with vomiting, low grade fever for three days and loss of consciousness for 18 hours. Clinically, the differential diagnoses were meningitis, encephalitis and septicemia. No history of past illness or any drug ingestion including aspirin were present. Laboratory investigations indicated a diagnosis of Reye syndrome. The child was given supportive treatment but died after two days of admission and postmortem needle-biopsy of the liver showed microvesicular steatosis consistent with Reye syndrome.
Highlights
Reye syndrome is a potentially fatal disease involving several organs, especially the liver and brain
4 Its incidence has shown a sharp decline in parallel with the decline in the use of aspirin in the pediatric age group.[5]
There was no evidence of bile duct proliferation, bile stasis, Kupffer cell proliferation, fibrosis, necrosis, or venous congestion. It was reported as microvesicular steatosis consistent with Reye syndrome
Summary
Reye syndrome is a potentially fatal disease involving several organs, especially the liver and brain. Reye syndrome presents as a dysfunction of the liver and metabolic encephalopathy in children. It is called a “twophase illness” since, in most cases, it is associated with a previous viral illness.[1,2] The cause is not exactly known and studies have suggested association with several factors, most importantly a history of prior aspirin ingestion.[3] Reye syndrome is no longer a specific clinicopathological entity but a descriptive term covering a group of heterogeneous disorders of infectious, metabolic, or toxic etiology. Cerebrospinal fluid examination showed low glucose level (4 mg/dL). There was no evidence of bile duct proliferation, bile stasis, Kupffer cell proliferation, fibrosis, necrosis, or venous congestion It was reported as microvesicular steatosis consistent with Reye syndrome
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