Abstract
In 1921, a Canadian research team led by Frederick Banting and John Macleod succeeded in the isolation of insulin from pancreatic homogenate [...].
Highlights
Emerging evidence suggests that beyond its counterregulatory role in glucose homeostasis, glucagon regulates a range of actions including lipolysis, ketogenesis, fatty acid oxidation, satiety, food intake, thermogenesis, energy expenditure (EE), and bile acid metabolism
In 2009, a novel peptide was characterized by Day et al that combined the antidiabetic and anorexic properties of GLP-1 with the thermogenic and lipolytic effects of glucagon (GCG) in a single molecule based on the GCG backbone [17]
More recent findings have established the value of adding the glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism to that of GLP-1/glucagon receptor (GCGR) [23]. These findings argue for a reevaluation of glucagon as a therapeutic target, a topic highlighted in this Special Issue
Summary
Emerging evidence suggests that beyond its counterregulatory role in glucose homeostasis, glucagon regulates a range of actions including lipolysis, ketogenesis, fatty acid oxidation, satiety, food intake, thermogenesis, energy expenditure (EE), and bile acid metabolism. This version was based on the oxyntomodulin sequence and contained full activity at both GLP-1 and GCG receptors and stimulated similar beneficial effects in diet-induced obese (DIO) mice as the “Day” molecule. Following on the heels of these preclinical rodent studies, it was observed that co-administration of GCG and GLP-1 in humans stimulated energy expenditure while reducing GCGR-associated hyperglycemia [19], confirming the translational importance of this strategy.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
