Abstract
The partition and permeation processes for ionizable tricyclic antidepressant amitriptyline hydrochloride (AMT•HCl) were studied. The apparent distribution coefficients in 1-octanol/aqueous buffer and n-hexane/aqueous buffer systems were determined at 6 temperatures (293.15–313.15 K). The thermodynamics and driving forces of the process were examined by calculating the main transfer thermodynamic parameters: ΔGtr0, ΔHtr0 and ΔStr0. The distribution experiments were carried out at different pH of the aqueous phase: pH 2.0, pH 4.0 and pH 6.8 from which the impact of the ionization state on the compound transferring was disclosed. To help explaining the distribution behavior, the data on the solubility in n-hexane (determined herein) and 1-octanol (from literature) were drawn into consideration. Two artificial membranes were used to investigate the permeability and to disclose the influence of the lipid layer in the content of the membrane.
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