Abstract
Revisiting Heterochromatin in Embryonic Stem Cells
Highlights
It is widely believed that chromatin in embryonic stem (ES) cells exists in a unique ‘‘open’’ conformation, characterized by sparse, disorganized heterochromatin and prevalent global transcription
ES cells respond by changes in gene expression, cell morphology, and chromatin structure, which may collectively contribute to a reduction in developmental plasticity [4,5]
Further studies have found that chromatin regions marked by other repressive modifications, such as H3K9me3 and H3K27me3, are larger in lineage-restricted human lung fibroblasts IMR90 when compared to human ES cells
Summary
It is widely believed that chromatin in embryonic stem (ES) cells exists in a unique ‘‘open’’ conformation, characterized by sparse, disorganized heterochromatin and prevalent global transcription. H3K9me2 is a relatively abundant modification associated with facultative heterochromatin that covers large, gene-poor regions of the genome [11].
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