Abstract
ABSTRACTGametocytes are the only form of the malaria parasite that is transmissible to the mosquito vector. They are present at low levels in blood circulation and significant knowledge gaps exist in their biology. Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed focus on malaria transmission biology as a basis for interventions. This review discusses recent insights into gametocyte biology in the major human malaria parasite, Plasmodium falciparum and related species.
Highlights
Over the past decade, mass roll-outs of effective control tools for malaria have resulted in a significant reduction of malaria disease and death, as well as transmission rates in most endemic countries
Recent reductions in the global malaria burden have brought the possibility of elimination and eradication, with renewed focus on malaria transmission biology as a basis for interventions
Our knowledge about parasite transmission biology is mostly based on Plasmodium falciparum and the rodent malaria model Plasmodium berghei
Summary
Mass roll-outs of effective control tools for malaria have resulted in a significant reduction of malaria disease and death, as well as transmission rates in most endemic countries. This review discusses recent insights into gametocyte biology in the major human malaria parasite, Plasmodium falciparum and related species.
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