Abstract

Theodor Boveri is considered as the “father” of centrosome biology. Boveri’s fundamental findings have laid the groundwork for decades of research on centrosomes. Here, we briefly review his early work on centrosomes and his first description of the centriole. Mainly focusing on centriole structure, duplication, and centriole assembly factors in C. elegans, we will highlight the role of this model in studying germ line centrosomes in nematodes. Last but not least, we will point to future directions of the C. elegans centrosome field.

Highlights

  • Boveri observed even smaller within the centrosome, which he first that the centrosomes can divide before their separation starts and that this stage of a doubled but not called “central granule” and later “centriole” [2]

  • Most of what we know about the structure and duplication of centrioles in C. elegans derives from studies on the germ-line centrioles of the early embryo and sperm

  • The past two decades have seen a rapid increase in our knowledge of centriole structure and assembly as well as pericentriolar material (PCM) composition and behavior

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Summary

Introduction

“In der ruhenden Zelle besteht ausserhalb des Kerns in der Zellsubstanz ein specifisches Körperchen, das ich ››Centrosoma‹‹ [ . . . ] nenne.” [1]. Boveri’s major discoveries on centrosomes were made using the early embryo of Ascaris megalocephala ( Parascaris equorum) for his light microscopy studies [3,4]. Nematodes are still favored by modern cell biologists, with the non-parasitic Caenorhabditis elegans emerging as a major genetic model system. This small free-living worm has contributed significantly to our. Cells 2018, 7, 101 knowledge of centrosome biology, as it offers a wide-range of tools for manipulating gene function and is highly amenable to various light and electron microscopy techniques. C. elegans will continue to contribute to a deeper understanding of the role of the centrosome in animal cell division and early development. Last but not least we will outline future directions of the C. elegans centrosome field

The Discovery of the Centrosome by Theodor Boveri—Early Observations
Return to Nematodes
The Core Centriole Assembly Pathway
Other Centriole Assembly Factors
PCM Recruitment
Concluding Remarks

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