Abstract
Given the limitations in our understanding of cancer development and treatment options, malignant neoplasms remain a leading cause of death worldwide. In 2016, to bolster our fight against cancer, we invited authors globally to identify the most crucial questions in cancer research and clinical oncology. This effort led to the review and publication of 101 key scientific questions, sparking a surge in promising research across various domains. With the significant growth in our knowledge and evidence over the past decade, we are excited to invite authors to revisit and refine their previously published key questions. We also encourage the submission of new key questions related to malignant diseases. The deadline for submitting these impactful questions is extended to the end of 2025.
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