Abstract
IntroductionThe optimisation of the treatment and the prevention of bipolar disorder typeI is essential. Several studies have described a possible relationship between genetic factors and lithium responders. The aim of this study is to present a systematic review on the evidence of this relationship. Material and methodsThe review is based on PRISMA recommendations. The PubMed, Scopus, Web of Science and PsycInfo databases were used. ResultsA total of 396 articles were found, of which only 5 were critically read, 2 of medium quality and the rest of low quality (due to the methods). DiscussionLike the studies included in the introduction, it can be shown that biomarkers of lithium response could lead to individualised treatment. ConclusionsVariants rs17026651, GADL1 IVS8+48delG and rs17026688 and patients carrying 5-HTT polymorphisms associated with reduced transcriptional activity could be useful biomarkers of lithium response in patients with bipolar disorder typeI. Further studies are required in order to check these results and to analyse other genetic relationships.
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