Revised Super-long Down-regulation Protocol Improves the Outcome of Infertile Patients with Repeated Implantation Failure in IVF/ICSI-ET

Abstract

Objective To investigate the outcome of revised super-long down-regulation protocol (RSDP) for in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET) in the special infertile patients with repeated implantation failure (RIF). Methods Patients with RIF were divided into RSDP group and routine long down-regulation protocol (RLDP) group. In RSDP group, gonadotropin releasing hormone agonist (GnRHa) was injected intramuscularly by 2.5 mg in mid-luteal phase for the first time and 1.25 mg after 28 d; gonadotropin (Gn) was started 14 d later after the second GnRHa dose. IVF/ICSI-ET was performed according to the routine procedure. The clinical outcomes of RSDP group were compared with those of RLDP group. Results In RSDP group, the number of retrieved oocytes and valid embryos was significantly lower (P 0.05); both good-quality embryo rate and implantation rate were significantly increased (P Conclusion RSDP can improve the IVF outcomes significantly in RIF patients.