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Abstract
By consensus, the acyl-CoA synthetase (ACS) community, with the advice of the human and mouse genome nomenclature committees, has revised the nomenclature for the mammalian long-chain acyl-CoA synthetases. ACS is the family root name, and the human and mouse genes for the long-chain ACSs are termed ACSL1,3-6 and Acsl1,3-6, respectively. Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made.
Highlights
Supplementary key words acyl-coenzyme A synthetase fatty acidcoenzyme A ligase coenzyme A synthetase bubblegum fatty acid transport protein very long chain-acyl-CoA synthetase long-chain acyl-coenzyme A synthetase lipidosin scFat2p
Related family members exhibit considerable overlap in their use of fatty acids of similar chain lengths, differences in the amino acid sequences of the AMP/ATP and fatty acid binding motifs distinguish subfamilies previously designated as acetyl-CoA synthetase, medium-chain acyl-CoA synthetase, long-chain acyl-CoA synthetase, very long-chain acyl-CoA synthetase, bubblegum, and scFat2p [6]
It should be noted that proteins of the family previously named very long-chain acyl-CoA synthetase (ACS) (VLCS) [6] are known as fatty acid transport proteins (FATPs)
Summary
The ACSL3, ACSL4, ACSL5, and ACSL6 genes encode mRNAs and proteins that have splice variants. The human ACSL3 gene encodes two transcripts with varying 5Ј untranslated regions, ACSL3 variant 1 (ACSL3_v1) and TABLE 1. Revised nomenclature for the long-chain acyl-CoA synthetase gene family
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