Abstract
A new (1972-1973), more potent inactivated influenza vaccine was evaluated for acceptability and effectiveness in stimulating serum and nasal antibodies. The vaccine contained 700 chick cell agglutination (CCA) units of A<sub>2</sub>Hong Kong antigen and 300 CCA units of B antigen (B/Mass/71). Injection of the vaccine into 100 middle-aged and elderly volunteers was well tolerated and effective in stimulating serum hemagglutination inhibition (HI) and nasal neutralizing antibody to the A<sub>2</sub>component. All men with undetectable serum HI titers of <10 and 62% of men with serum HI titers of ≤ 160 had serum antibody responses. A direct correlation between serum HI antibody titers and nasal neutralizing antibody titers was demonstrated. All men with ≥ 16-fold serum rise had ≥ 4-fold nasal antibody rises. Since both serum and nasal antibodies may have protective roles, influenza vaccines should induce high titers of both systemic and local antibodies.
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