Abstract
It should be recalled that each tooth is an organ with several types of tissue represented and is endowed with an excellent vascular and nerve supply. It contains its own sources of progenitor cells which undergo proliferation, differentiation, growth, and secretion in a highly regular manner. In the developing or in the continuously growing tooth all stages of cellular development can be observed simultaneously. The metabolic products of cellular activity, dentin and enamel, constitute a record of the secretory activity of odontogenic cells so that disturbances in productive metabolism can be identified by faults in the dentin and enamel matrices. Ameloblasts, which form the hardest matrix material (enamel) found in the body, are epithelial cells derived from the ectoderm; odontoblasts, which form dentin, are derived from the mesodermal layer. Hence, the action of radiation during the various stages in the life cycle of two cell lines of independent embryonic origin can be studied concurrently. Alterations in the regular pattern of either cell line, or both, can result in gross changes in tooth morphology by interference with normal tooth development and growth.
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