Abstract
Neuromedin B (NMB) is purified from porcine spinal cord as a potent stimulant factor for uterine contraction. In the pig, NMB exists at least in three forms, 10, 30, and 32 aa in length. NMB is present in mammals, and the structurally related peptide ranatensin is present in amphibians. NMB binds the NMB-preferring receptor (NMBR) with high affinity, and also binds gastrin-releasing peptide-preferring receptor with less potency. NMB mRNA is expressed in the central nervous system and gastrointestinal tract. In rat brain, its expression is prominent in the olfactory bulb and dentate gyrus, and moderate expression is detected in the wider area. NMB regulates smooth muscle contraction, exocrine and endocrine secretion, blood glucose, body temperature, food intake, energy homeostatis, grooming and scratching, emotion, nociception, and cell growth. NMBR is expressed in various human cancers and carcinoid tumors, and may have a growth effect. NMB is implicated in human thyroid disorder.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
