Reviewing and Previewing the History of Data Processing in Nmr Spectroscopy

Abstract

For all practical purposes (but somewhat arbitrarily), the history of NMR spectroscopy may be divided into six periods: 1.) 1946∼1950 Invention and initial physical measurements 2.) 1951∼1960 Initial chemical applications of proton NMR, first commercial instruments 3.) 1961∼1968 Routine chemical applications of proton NMR, some heteronuclei NMR, signal averaging 4.) 1969∼1975 Fourier Transform (FT) NMR and practical 13C NMR applications 5.) 1975∼1983 NMR of less receptive nuclei, beginnings and growth of 2D FT NMR, NMR of Biopolymers 6.) 1985-current 2D FT NMR Methods and Applications; widespread chemical shift imaging, mature 500 MHz NMR spectrometers; solution “X-ray” structures of small proteins.