Abstract
Statins play an important role in prevention of cardiovascular and cerebrovascular diseases for their excellent lipid-lowing efficacy. However, statins can increase the risk of the occurrence of acute kidney injury (AKI) with significant dose correlation. Statins related AKI is associated with acute tubular necrosis when rhabdomyolysis occurred. Statins can lead to proteinuria or elevated serum creatinine levels, most of the changes are transient. Statins related proteinuria is caused by protein malabsorption in renal tubules. Renal safety of statins is different, rosuvastatin and simvastatin are more likely to cause renal adverse reactions. Atorvastatin and fluvastatin are safer to kidney with little renal excretion. Patients with chronic kidney disease are safe to use statins since they could reduce the risk of cardiovascular events. However before statins therapy starts, risk and benefit evaluation should be carried out, and attentions should be paid to drug selection and dose adjustment. Key words: Acute kidney injury; Patient safety; Statins
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