Abstract
In “Buprenorphine versus methadone for the treatment of opioid dependence: a systematic review and meta‐analysis of randomized and observational studies,” authors Louisa Degenhardt and colleagues reviewed studies to compare the effectiveness of methadone with buprenorphine. Their study, published in the June 2023 issue of Lancet Psychiatry, found that treatment retention was better with methadone than buprenorphine. The study was a meta‐analysis that identified 32 randomized controlled trials (RCTs) of 5,800 participants and 69 observational studies of 323,340 participants. Primary outcomes were.
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