Review on Thiazolidinone possessing heterocyclic analogues, their potential binding sites with Cyclooxygenase and Lipoxygenase; Their SAR and Docking studies for Anti-inflammatory activity

Abstract

This review summarizes the work done in the last few years to overcome the limitations and side effects of marketed drugs, including the structure, structure-activity relationship and molecular docking study of some thiazolidinone-based derivatives. Molecular docking analysis is useful in the prediction of binding affinity, the detection of fragments responsible for the interaction with enzyme binding sites, their modes of interactions with the active site, and the efficacy of compounds in inhibiting cyclooxygenase (COX), lipoxygenase (LOX), and tumor necrosis factor (TNF-α). Inhibition might be a promising for the treatment of multifactorial diseases such as inflammation. Some of these compounds exhibit COX and LOX dual inhibition actions. This study discloses some structural features for binding to 15-LOX, COX, and TNF-α, thus providing the way to design new anti-inflammatory agents with better inhibition of these enzymes.