Review on the One-year Repeated Dose Oral Toxicity Study in Dogs for the Toxicological Evaluation of Pesticides (Agricultural Chemicals) (Decision of the Expert Committee on Pesticide, FSCJ, 21 December 2017).

Abstract

In the toxicological evaluation of pesticides (agricultural chemicals), their toxicities have been evaluated based on studies in rodents such as rats and mice as well as in non-rodents such as rabbits and dogs. Here, reflecting a research performed under the Food Safety Commission of Japan (FSCJ) grant on pesticide toxicity study1), international trends and also scientific points of view, the necessity of chronic dog toxicity studies was reconsidered for the use in toxicological evaluation of pesticides.