Review on the fish collagen-based scaffolds in wound healing and tissue engineering

Abstract

Collagen from marine organisms is an emerging source in tissue engineering, an alternative to bovine and porcine collagen. Despite the positive results on wound healing from fish collagen scaffolds, the comprehension and advancements in its properties are limited. Given this context, this study aimed to carry out a systematic review to examine the effects of collagen scaffolds on different models of experimental skin wounds, the advantages and its limitations. The search was conducted according to the orientations of Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) and the MeSH (Medical Subject Healings) terms used were “Fish Collagen” AND “Wound Healing” AND “Scaffold”. 36 articles in total were sorted out from the databases of Google Scholar and PubMed. After the analysis, the current review covers 10 articles from the beginning of 2017 to March 2023. The results are mainly focused on the different methods of collagen extraction, preparation of scaffolds and its treatment on the animal model along with its effects. To infer, this current review states that, despite the positive effects of collagen on tissue repair and regeneration, no product is available for medical purposes. Thus, this review also demonstrates the huge potential for collagen in tissue engineering.