Abstract
Benzotriazole is nitrogen containing heterocycle derivative containing three nitrogen atoms at 1st, 2nd, 3 rd positions. Lone pairs of each nitrogen atom are present in unshared form. The unshared lone pair of electrons enables five-membered ring to exhibit that can exist in tautomeric forms. Benzotriazole belongs to a fused heterocycles, which has a benzene ring fused with with a traizole ring. Benzotriazole and its derivatives have great significance in medicinal chemistry. The derivatives are used by several chemists for therapeutic conditions. The current paper concise several synthetic methods utilized for synthesizing derivativeswhich acts as antimicrobials, antibacterial, antifungal, antiviral, antitubercular, anticancer, anti-inflammatory, anticonvulsant, analgesic and antioxidant agents. The article will also help the researchers to understand the structure activity relationships and improvise the conceptsin their researches.
Highlights
As the micro-organisms are rapidly undergoing genetic changes and developing resistance against many antibiotics and therapeutic agents for various diseases more quickly than new drugs are being made available so the war against the infectious diseases has become a never ending process
Some amide benzotriazole derivatives synthesized from sydnone fragment were reported to display good antitubercular activities
The plethora of research subscribed in this review indicates a wide spectrum of pharmacological activities exhibited by benzotriazole derivatives
Summary
As the micro-organisms are rapidly undergoing genetic changes and developing resistance against many antibiotics and therapeutic agents for various diseases more quickly than new drugs are being made available so the war against the infectious diseases has become a never ending process. Benzotriazole and its derivatives have great significance in medicinal chemistry [1]. The high therapeutic properties of the related drugs have encouraged the medicinal chemists to synthesize the large number of novel chemotherapeutic agents [2]. Nitrogen and sulfur containing organic compounds and their metal complexes display a wide range of biological activity as antitumor, antibacterial, antifungal and antiviral agents [3]. Benzotriazoles are often used as corrosion inhibitors, radioprotectors, and photo stabilizer in the production of plastic, rubber and chemical fiber 3. Along with these activities, benzotriazole is important as a precursor in the synthesis of peptides, acid azides, preparation of 3hydroxymethyl-2,3-dihydrobenzofurans and 3-hydroxymethylbenzofurans [4]. Benzotriazoles containing Mannich bases have recently been synthesized by amine exchange reactions, from the N,N-dimethylaminopropiophenone hydrochlorides and benzotriazole, respectively [7]
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