Review on Synthesis of Thiazole Derivatives from α-Halo- ketones and Thiourea or N-Substituted Thiourea

Abstract

Thiazole represents important class of heterocyclic compounds. Thiazole and its derivatives have been reported to possess antitubercular, antibacterial, anti-inflammatory, anticancer, antifungal activity. Several methods of synthesis of thiazole derivatives have been reported, but most widely used synthetic approach to obtained thiazole derivatives is Hantzsch process. It involved synthesis of thiazole derivative from ?-halo-carbonyl compounds and thiourea or thiourea derivatives. This review mainly focuses on the research work reported in the scientific literature on the different procedures of synthesis of 2-amino thiazole and their derivatives.