Abstract
Oral insulin is one of the most exciting areas of diabetes therapy, due to the potential benefits of patient convenience, liver rapid insulination, appropriate insulin delivery to avoid hyperinsulin hypertension in the peripheral region, and the potential to avoid the harmful effects of weight gain and low blood sugar. Evidence is growing that early intensive insulin therapy leads to sustainable and tight blood glucose control and leads to serious complications, making effective oral insulin products even more important for the treatment of diabetic patients. Despite the knowledge of this medical need, insulin injections have failed due to several obstacles. For decades, researchers have tried to develop oral insulin with various technologies, but have not succeeded in clinical and commercial studies. The review summarizes the development status of oral insulin and indicates that it is under clinical trial
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