Abstract
Metosartan induces so many deleterious effects in male Wistar rats treated with drug and RNase. It causes pre maturation of sperms and reduces the sperm count as well as reduces viable sperm count. It induces the x-chromosome desynapsis leading to testicular carcinoma. The effects are so profound in case of drug than compared to the enzyme RNase. Metosartan induces apoptosis in testicular tissue mainly through intrinsic pathway which is mainly due to genotoxic agents. The drug mainly inhibits RNase A in rat testes and has positive effect on Mitosis.
Highlights
Introduction through regeneration of glutathioneNucleotides like NADPH binds to Cyt C and prevent its binding to APAF1 inhibiting apoptosis
Metosartan induced apoptosis in testes tissue treated in-vivo with the drug through oral gavage and caused desynapsis of the x-chromosome in sperms leading to genetic aberrations in the offspring [7]
Identification of RNase present in testes is a crucial thing as the drug intake disturbs chromatin integrity
Summary
Introduction through regeneration of glutathioneNucleotides like NADPH binds to Cyt C and prevent its binding to APAF1 inhibiting apoptosis. After treatment with metosartan using aniline blue staining resulted in pre maturation in sperms compared to RNase A. From the recent reports of mine RNase A in rats was successfully isolated from the testis with molecular weight of 24 kDa. The isolated enzyme was subjected to agarose gel electrophoresis followed by metosartan treatment resulted in no catalytic activity of the enzyme with regard to cleavage of substrate RNA.
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