Review on Computer-Aided Drug Designing for Targeted Drug Delivery Systems

Abstract

The article provides an overview of computer-aided drug design (CADD) and its applications in designing targeted drug delivery systems (TDDS). CADD is a process that uses computational tools and techniques to design drugs and predict their biological activity, pharmacological properties, and toxicity. TDDS is designed to deliver drugs specifically to the affected site, reducing the side effects associated with traditional drug delivery methods. The article also covers the history of CADD, the software and aids used in CADD, and the parameters involved in CADD for TDDS. The overview steps involved in CADD are also discussed, including target identification, virtual screening, drug optimization, validation, and regulatory approval. As well as The article provides an overview of computer-aided drug design (CADD) for targeted drug delivery systems (TDDS). CADD is a process of designing drugs using computational tools and techniques to predict the biological activity, pharmacological properties, and toxicity of potential drug compounds. TDDS is designed to deliver drugs specifically to the affected site, reducing the side effects associated with traditional drug delivery methods. Different types of drug delivery vehicles, such as polymeric micelles, liposomes, lipoprotein-based drug carriers, nano-particle drug carriers, dendrimers, etc., are used in TDDS. The article also covers the history, software, and aids used in CADD, and the overview steps involved in CADD for TDDS. Parameters for CADD for TDDS include target identification, drug release kinetics, biocompatibility, pharmacokinetics, targeting efficiency, and drug toxicity.