Abstract
This review focuses on the importance of local drug delivery in the treatment of Gastro intestinal diseases ulcerative colitis, Crohn’s disease, amebiasis, colon cancer. For many types of drugs, oral administration is the most common route of administration due to patient compliance and flexibility. Targeted drug delivery system is a system that sends drugs to diseased areas by changing the amount of information. The large intestine is where local drug delivery and systemic diseases can occur. Treatment will be better if the drug directly targets the intestine. The large intestine is where the local child allows local treatment of intestinal diseases and the distribution of drugs. Gastrointestinal therapeutic drugs are effective when they can be directly targeted to the intestine, because drug release and absorption should not occur in the stomach and small intestine and the bioactive agents should not be broken down and released into the intestine. Drugs targeting the intestinal area not only affect the treatment of local diseases, but also deliver drugs such as proteins and peptides to the body due to their effects on the body. At the same time, due to weakness of the digestive system, these drugs are broken down and their availability is quiet low.
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