Review on adverse drug reactions induced by anti-tuberculor drugs

Abstract

Introduction: Tuberculosis is a chronic, highly contagious disease caused by the Bacillus Mycobacterium tuberculosis and spreads from person to person through air. Tuberculosis affects lungs majorly but also affects other parts of the body, such as brain, intestine, spine and kidney. The main cause for patient’s non-adherence to anti-tuberculosis therapy is ADRs of varying degrees of severity such as hepatotoxicity etc. Aim: This study aimed to provide proper understanding of Adverse drug reactions resulted due to Anti-TB drug therapy in TB patients based on various studies done on Anti-TB agents induced ADRs. Conclusion:Anti- Tuberculosisdrug (Anti-TB)could cause several ADRs both mild and severe types majority of ADR were wild, more attention is needed to prevent ADR and enhance current Anti-TB therapy. The study suggests that for more better in depth understanding and prevention of Anti-TB drug ADR many more studies with larger population is needed, also the current Anti-TB therapy requires some revisionto prevent fatal hepatotoxicity.