Abstract
Poor permeability of orally administered drugs is the major factor limiting the bioavailability of orally administered drugs. The unique barrier properties of the gastro-intestinal membrane, intestinal and presystemic metabolism, intersubject variability also contributors to poor permeability and bioavailability of the drugs. Bioenhancer can benefit the drugs with this problem, especially BCS class III and class IV drugs. Different mechanisms have been established to understand the permeation enhancement effect of different permeation enhancers; their understanding can facilitate the selection of suitable absorption promoters for drugs having specific physicochemical properties. However, certain issues associated with development of absorption promoter technology like lack of in vitro and in vivo correlation of efficacy, reproducibility, and safety. Therefore instead of chemical permeation enhancer herbal bioenhancer is more acceptable due to their better safety profile.
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