Abstract
This review is dedicated to the 90th anniversary of the outstanding experimental physicist Boris Anatolyevich Dolgoshein, in whose laboratory exactly 50 years ago the first two-phase emission detector has been created. Today two-phase emission detectors found the best application in the most sensitive at the moment experiments searching for cold dark matter in the form of weakly interacting massive particles (WIMPs). Multi-ton active mass WIMP detectors of the upcoming G3 generation shall become sensitive to solar neutrinos interactions, to double-beta decay of isotopes containing in the working media with naturally occurring isotope abundances. The RED-100 detector constructed at NRNU MEPhI will be used for investigation of the reactor neutrino elastic coherent scattering off xenon nuclei at the Kalinin NPP in 2021. ProtoDUNE-DP prototype emission detector (6x6x6 m3 300 tons LAr) is currently being assembled at the CERN Neutrino Platform in support of the DUNE project focused on investigation of high energy neutrino oscillations. Thus the detector technology invented at MEPhI 50 years has demonstrated a great potential to be used in a variety of fundamental research programs.
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