Review of the Roles and Interaction of Androgen and Inflammation in Benign Prostatic Hyperplasia.

Yu Tong,Ren-Yuan Zhou,Agnieszka Dobrzyn

doi:10.1155/2020/7958316

Abstract

The lower urinary tract symptoms (LUTSs) and acute urinary retention (AUR) caused by benign prostatic hyperplasia (BPH) can seriously affect the quality of life of elderly men. Studies suggest that both androgens and inflammation greatly influence the occurrence and development of BPH in most patients. These two factors combined can also affect each other, leading to pathological changes in the stromal and epithelial tissue of the prostate transition zone in BPH patients. DHT in the prostate tissue of BPH patients may activate a chronic inflammatory response in the prostate, amplifying the expression of inflammatory factors and upregulating the proliferation ability of prostate tissue.

Highlights

Benign prostatic hyperplasia (BPH) is the most common urinary system disease in elderly men [1], and its main pathological manifestations are proliferative hypertrophy and nodule formation in the transition zone of the prostate
BPH increases the risk of urinary tract infection (UTI) and acute urinary retention (AUR)
Some evidence suggests that metabolic syndrome and chronic inflammation play a role in the occurrence and progression of BPH/lower urinary tract symptoms (LUTSs) [6]

Summary

Introduction

Benign prostatic hyperplasia (BPH) is the most common urinary system disease in elderly men [1], and its main pathological manifestations are proliferative hypertrophy and nodule formation in the transition zone of the prostate. The occurrence and development of BPH are closely related to age. BPH is the most common cause of lower urinary tract symptoms (LUTSs) in men. The cellular and molecular mechanisms of BPH are still unclear, changes in androgen levels and senility-related tissue remodeling have been considered to be important factors contributing to homeostasis disorders in the prostate [5]. Some evidence suggests that metabolic syndrome and chronic inflammation play a role in the occurrence and progression of BPH/LUTS [6]. This review focuses on the interactions between androgens and inflammation as well as their individual roles in BPH and LUTS development and explores the relationship between androgens and inflammation in BPH pathogenesis

The Role of Androgens in BPH

The Role of Inflammation in BPH

The Combined Effect of Androgens and Inflammation

Findings

Conclusion