Abstract
Corneal Neovascularization (CNV), the extensive growth of blood vessels from conjunctiva into the cornea. It is a sight-threatening condition that can decreases eyesight and even leads to blindness. The pathologic growth of blood vessels impairs light transmission, promotes scar formation and causes inflammations, which harm visual acuity. Abnormal angiogenesis plays an important role in the process of CNV, which may result from corneal wound healing. Neovascular eye disease is one of the most common eye diseases in clinical admissions. CNV blinds approximately 7 million people worldwide. Continued mechanistic studies are a key to the prevention and treatment of CNV. Research in CNV animal models is essential in eye diseases. Several main methods of CNV models preparation are summarized in this review.
Highlights
Vasculogenesis is a natural process associated with growth, reproduction and the repair of damaged tissue
Additional hormone-like activity influences corneal diaphaneity (Hecquet et al, 1990; Bremnes et al, 2006). basic Fibroblast Growth Factor (bFGF) promotes the secretion of collagen fiber. bFGF induces endothelial cells to produce a large number of urokinase type fibrinolytic enzyme activators which work in early angiogenesis to dissolve collagenase enzyme
Corneal Neovascularization (CNV) models induced by suture and chemicals are widely used in corneal experiments
Summary
Vasculogenesis is a natural process associated with growth, reproduction and the repair of damaged tissue. Trauma and inflammation cause new blood vessels to invade the cornea, resulting in pathological CNV. Inflammatory CNV Model Induced by Physical Methods There are few research reports about secondary angiogenesis after corneal thermal burn which restricts the basic study of the new blood vessels after thermal burn. Chemical Burns Method: In this method, alkaline chemicals are applied to burn the cornea and induce new blood vessels.
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