Abstract
Ionizing radiation damage refers to acute, delayed, or chronic tissue damage associated with ionizing radiation. Specific or effective therapeutic options for systemic injuries induced by ionizing radiation have not been developed. Studies have shown that Chinese herbal Medicine or Chinese Herbal Prescription exhibit preventive properties against radiation damage. These medicines inhibit tissue injuries and promote repair with very minimal side effects. This study reviews traditional Chinese herbal medicines and prescriptions with radiation protective effects as well as their mechanisms of action. The information obtained will guide the development of alternative radioprotectants.
Highlights
Ionizing radiation is essential in clinical diagnoses and treatment
We summarized recent advances that have been aimed at elucidating the functions and mechanisms of effective active ingredients of Chinese herbal medicines and prescriptions in preventing ionizing radiation associated damage
Astragaloside IV is an active ingredient in Astragalus mongholicus Bunge that is involved in controlling apoptosis or cell cycle, down-regulation of the Bax/Bcl-2 ratio, inhibition of G0/G1 cell-cycle arrest, increasing the proliferative ability of bone marrow cells, and in protection against radiation induced damage to the hematopoietic system (Li et al, 2011)
Summary
Ionizing radiation is essential in clinical diagnoses and treatment. It is an effective therapeutic strategy for cancer treatment. Inhibit the secretion of pro-inflammatory factors, reduce the damage of pulmonary fibrosis caused by peroxide Improve the ROS - mediated side effects of ionizing radiation via MAPK/NF-κB signaling pathway Promote the self-renewal and proliferation of cells
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