Abstract

Primordial germ cells (PGCs), which are the precursors of mammalian eggs and sperm, are essential for early development of the reproductive system. The gametogenic disorder is a great challenge for assisted reproductive technology. Due to ethical and technical limitations, the origin and specialization mechanisms of PGCs in human embryos remain unclear. Differentiation of the primordial germ cell like cells (PGCLCs) in vitro and further study of mechanisms of their development become possible, with the establishment and improvement of the in vitro culture technology for pluripotent stem cells, which also bring hope for the clinical treatment of the gametogenic disorders. The in vivo development of PGCs, the differentiation process of pluripotent stem cells into PGCLCs in vitro, the main differentiation methods and specific markers of PGCLCs will be reviewed in this paper. Key words: Primordial germ cells; Embryonic stem cells; Induced pluripotent stem cells; Primordial germ cell like cells

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.