Abstract

The high prevalence of atrial fibrillation (AF) in the overall population and its association with substantial morbidity, increased mortality and health care cost has instigated significant basic and clinical research efforts over recent years. The publication of multiple new high-quality randomized multi-center trials in the area of AF management and the rapidly evolving technological progress in terms of diagnostic possibilities and catheter ablation in recent years demanded a revision of the previous ESC AF Guidelines from 2016. The 2020 guidelines provide up-to-date, evidence-based guidance for the management of AF. One of the most important innovations is the presentation of a new concept for structural characterization of AF (the “4S AF scheme”) replacing the traditional classification based on its temporal pattern alone (paroxysmal-persistent-permanent). The 4S-AF-scheme highlights the importance of systematic assessment of stroke risk, severity of symptoms, total AF burden and underlying substrate as the foundation for effective and individualized AF treatment for each and every patient. Further novelties relate to the presentation of an easy and intuitive management pathway (“ABC pathway”) and strengthening the recommendations for early rhythm control, in particular the role of first line catheter ablation in heart failure. Another core component of the guidelines is the focus on patient involvement to achieve optimal outcomes. Patient education, shared decision making and incorporation of patient values and patient reported outcome of treatment interventions as well as integrated care by a multidisciplinary team all have a central role in the proposed management pathway for AF.

Highlights

  • Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults and the number of patients affected continues to rise with a currently estimated life time risk of 1 in 3 [1]

  • In brackets/bold letters = class of recommendation and level of evidence of ESC Guidelines 2020. * Choice of drugs based on comorbidities including HFrEF, severe COD/Asthma, pre-excited atrial fibrillation (AF). + Factors favoring rhythm control: Patient’s choice, symptomatic AF, young age, first episode, tachycardia-mediated cardiomyopathy, difficult rate control, normal to moderate increased LAVI, no or few comorbidities, AF precipitated by temporary event; Abbreviations: NOAC, novel oral anticoagulants; VKA, Vitamin K antagonists; NDCC, non dihydropyridine calcium channel blocker; CAD, coronary artery disease; VHD, valvular heart disease; HFp/rEF, heart failure with preserved/reduced Ejection Fraction

  • The assumption that rate and rhythm control were equal in terms of prognosis was based on multiple large randomized studies from the early 2000s comparing medical rhythm vs rate control in non-heart failure patients [56] and heart failure patients [57]. This has been attributed to the practice of stopping anticoagulation after successful rhythm control in these trials, the per se lower success rates of antiarrhythmic drugs compared to catheter ablation, as well as their pro-arrhythmogenicity and side effects, if used in combination, all of which might have offset the benefits or rhythm control for AF

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Summary

Introduction

Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults and the number of patients affected continues to rise with a currently estimated life time risk of 1 in 3 [1]. It is recommended that these patients undergo screening for risk factors and co-morbidities associated with AF, but it remains controversial which exact burden of AHRE and subclinical AF mandates medical treatment. It is unknown whether any rate or rhythm control intervention at this stage may prevent progression to clinical AF and no recommendation in regards to their initiation are given. Higher AF burden have been associated with higher stroke risk [149o] fa1n5d mortality rates (if >6–24 h of AF per week) [20], poorer response to rhythm control therapy [21] and may represent progression of advanced atrial remodeling [22]. Extended triple therapy with Aspirin, Clopidogrel and an oral anticoagulation for longer than 1 week after an ACS should be considered when risk of stent thrombosis outweighs the bleeding risk, with the total duration ≤1 month

Better Symptom Control
Rate Control
Rhythm Control
Cardiovascular Risk Factors and Comorbidities
Findings
Conclusions
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