Review of Systemic Therapy for Cutaneous T-Cell Lymphomas

Abstract

The cutaneous T-cell lymphomas (CTCL) mycosis fungoides and Sezary's syndrome are low-grade, non-Hodgkin lymphomas with a mature helper T-cell phenotype that always have a cutaneous component. Systemic involvement occurs early in disease, often before it is evident clinically. Systemic therapy is frequently used to treat CTCL, but there has been a longstanding de-bate as to whether early aggressive systemic therapy is warranted. In this …