Abstract
Review of: "Robust statistical evaluation of tumor incidences in long-term rodent carcinogenicity studies: the reformulated poly-k trend test"
Highlights
Potential competing interests: The author declares that he works for an agrochemical company conducting chronic rodent cancer bioassays in the context of human safety assessment
When statistics is used as a screening tool to focus the evaluator on tumor types that need a closer look, pragmatic models may do the job
A common error in interpretation is the expectation that toxicity reduces the lifespan and that tumors are the main cause for mortality
Summary
I personally would recommend to add a few more sentences for those readers not fully familiar with factors driving survival in carcinogenicity studies. Review of: "Robust statistical evaluation of tumor incidences in long-term rodent carcinogenicity studies: the reformulated poly-k trend test" Potential competing interests: The author declares that he works for an agrochemical company conducting chronic rodent cancer bioassays in the context of human safety assessment.
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