Review of Efficacy and Comparison of Intracameral Antibiotics for Postcataract Surgery Endophthalmitis Prophylaxis

Abstract

Justify universal adoption of intracameral antibiotic for prophylaxis against postcataract endophthalmitis. Review of both placebo-controlled randomized clinical trials for intracameral cefuroxime and moxifloxacin as well as large retrospective studies demonstrate efficacy in reducing the risk of postcataract endophthalmitis when the intracameral antibiotic choice is targeted to the causative pathogens of the demographic studied. Clinical evidence demonstrates the benefit of intracameral antibiotic use from statistical, clinical, and cost-effective analyses. Cases with higher risk for endophthalmitis such as posterior capsule rupture, manual extracapsular cataract extraction, immunocompromised patients, and age > 85, warrant special attention and greater consideration for intracameral antibiotic use. Further research to identify the optimal drug, formulation, and concentration can improve patient outcomes.