Review of clinical trial experience with icodextrin

Abstract

Icodextrin-based dialysis solutions have been introduced toneal dialysis (CAPD). A total of 209 patients in theto address an unmet clinical need in peritoneal dialysis, United Kingdom were enrolled and were treated for upnamely the difficulties inherent in ultrafiltration manage- to six months. The objectives of the study were to evalu-ment during the long dwell [1–4]. These solutions take ate the efficacy of 7.5% icodextrin compared with lowadvantage of the physiologic principle of colloid osmosis (1.5%) or high (4.25%) dextrose solutions when the dwelland the high reflection coefficient of the glucose poly- time was 8 or 12 hours overnight. Approximately 40%mers allows for ultrafiltration to proceed with dialysis of patients in the dextrose group used 4.25% dextrosesolutions iso-osmotic to plasma. While the efficacy and bags overnight prior to the study and the other patientssafety of icodextrin have been described in multiple pub- used 1.5% dextrose bags overnight prior to the study.lications (abstracts; Douma et al,