Abstract
Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first choice of treatment for rheumatic disorders and other degenerative inflammatory diseases. One of them, indomethacin (INDO), is highlighted in this study. With its analgesic, antipyretic, and anti-inflammatory properties, it is one of the most powerful drugs used in various clinical trials and therapies related to the mechanism of blocking prostaglandin synthesis, thus reducing and eliminating many inflammatory conditions in patients. To ensure the efficacy and safety of this drug in pharmaceutical and clinical use, precise product quality control is required. Such control is performed with routine pharmaceutical analysis using various chemical methods by which INDO is identified as a separate active ingredient in the multicomponent system of a complete pharmaceutical form. In addition, the determination of INDO is important in clinical practice, where its concentration is determined in different biological samples, ensuring better monitoring of a particular therapy. The most commonly used methods for the determination of INDO are high-performance liquid chromatography (37% of developed methods), voltammetry (16% of developed methods), and UV spectroscopy (11% of developed methods). However, each of these methods must provide precise validation parameters. A combination of analytical methods can lead to more precise results and safer application in practice.
Highlights
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first choice of treatment for rheumatic disorders and other degenerative inflammatory diseases
Classification is most commonly based on chemical structure and selectivity: salicylates, nonacetylated salicylates, propionic acids, acetic acids, enolic acids, anthranilic acids, naphthylalanine, and selective cyclooxygenase-2 inhibitors [3]. Their mechanism was described for the first time in 1971 [4,5,6], when it was shown that this type of drug inhibits the biosynthesis of prostaglandins by preventing binding of the substrate, arachidonic acid, to the active site of the enzyme cyclooxygenase (COX) [7]
This study presents a review of the characteristics and properties of INDO and, for the first time, highlights the analytical methods described in the literature for INDO determination between 2000 and 2020
Summary
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first choice of treatment for rheumatic disorders and other degenerative inflammatory diseases. Classification is most commonly based on chemical structure and selectivity: salicylates, nonacetylated salicylates, propionic acids, acetic acids, enolic acids, anthranilic acids, naphthylalanine, and selective cyclooxygenase-2 inhibitors [3] Their mechanism was described for the first time in 1971 [4,5,6], when it was shown that this type of drug inhibits the biosynthesis of prostaglandins by preventing binding of the substrate, arachidonic acid, to the active site of the enzyme cyclooxygenase (COX) [7]. To safely use NSAIDs in the pharmaceutical industry and clinical therapies, it is necessary to develop accurate and reliable analytical methods for their determination in different types of samples. It could be very useful for researchers to realize the key concepts in INDO determination
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