Abstract
AbstractMorus, a plant genus from the family of Moraceae, most plants of which are used as traditional medicines in Asian counties. The root barks of Morus plants are normally called as Sang-Bai-Pi (SBP) in Chinese and used for the treatment of inflammatory and respiratory diseases. Decades of research on phytochemistry of SBP have led to the identification of various compounds, such as Diels–Alder-type adducts, flavonoids, benzofurans, stilbenes, polyhydroxylated alkaloids, etc. These compounds have showed a wide range of bioactive features including anti-inflammatory, anti-oxidative, anti-microbic, etc. This review focus on the bioactive compounds and their pharmacological effects of SBP which will help us fully understand the effective substances of SBP, and pave our way to further explore medicinal uses of SBP and comprehensive utilization of Morus species.
Highlights
Morus Linn, a plant genus from family Moraceae, consists of 10–16 species recognized by botanists including Morus alba L., Morus nigra L., Morus cathayana Hemsl., Morus wittiorum Hand.-Mazz., Morus mongolica (Bur.) Schneid., Morus australis Poir., etc. (Datwyler & Weiblen, 2004)
M. alba, a perennial herb, is the dominant specie among the genus Morus. It is distributed throughout Asia, Africa, Europe and South and North America, and found in wide range of areas (Zafar et al, 2013)
There over 110 compounds, mostly Diels–Alder-type adducts, flavonoids, 2-Arylbenzofurans, and stilbenes, with anti-inflammatory, anti-oxidative, anti-microbic, anti-diabetic, anti-tumor, and other pharmacological effects are summarized in this paper
Summary
Morus Linn, a plant genus from family Moraceae, consists of 10–16 species recognized by botanists including Morus alba L., Morus nigra L., Morus cathayana Hemsl., Morus wittiorum Hand.-Mazz., Morus mongolica (Bur.) Schneid., Morus australis Poir., etc. (Datwyler & Weiblen, 2004). Root barks of Morus plants are usually called Sang-Bai-Pi (Mori Cortex) It has been recorded in Chinese Pharmacopoeia and widely applied in traditional Chinese medicine since 500 B. Root barks of M. alba (Sang-Bai-Pi or Mori Cortex) have been recorded in Chinese Pharmacopoeia and widely applied in traditional Chinese medicine since 500 BC for the treatment of lung heat, cough, edema, and oliguria There over 110 compounds, mostly Diels–Alder-type adducts, flavonoids, 2-Arylbenzofurans, and stilbenes, with anti-inflammatory, anti-oxidative, anti-microbic, anti-diabetic, anti-tumor, and other pharmacological effects are summarized in this paper This will help us fully understand the effective substances of SBP, and pave our way to further explore medicinal uses of SBP and comprehensive utilization of Morus plants. Besides the compounds motioned above, there are other types of bioactive compounds [110, 112–117] isolated from SBP (Figure 5)
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