Review of Arsenic Induced Alternation In Animals By Its Toxicity

Abstract

This study assessed the developmental and behavioral effects of chronic arsenic exposure in animals. Therefore, the current research is to study the effects of arsenic trioxide on nephrotoxicity, hepatoxicity, and nephrotoxicity. Attempts to monitor the effect of arsenic are based on extensive literary research, with special emphasis on the latest works. Arsenic is a carcinogen to both humans and animals. Arsenicals have been associated with skin, lung, and bladder cancers of the skin, lung, and bladder. Arsenic (As) is classified as a metalloid and exhibits both metallic and nonmetallic properties. It is found in ore and crust rocks with average density. It exhibits a complex chemistry, occurring in four different valences (-III, O, III and V), and in many different chemical forms and it has these being used for a wide variety of industrial and agricultural purposes. Arsenic oxide (As2O3) is the most important arsenic compound used in industry and is used to synthesize other inorganic and biological weapons. Arsenic trioxide is now used to treat acute promonocytic leukemia. Absorption occurs primarily through ingestion in the small intestine, although less absorption occurs through skin contact and respiration. Acute arsenic poisoning was initially associated with nausea, vomiting, abdominal pain, and severe diarrhea, and peripheral neuropathy was reported. Chronic arsenic poisoning can cause multisystem disease. Affects signaling pathways by being able to activate proteins such as ERK2, p38, and JNK as shown in mammals. A comparison between the phosphorylation sites of these proteins is performed to determine whether they are observed in water and in mammals.