Review: Comprehensive treatments for youth comorbidity - evidence-guided approaches to a complicated problem.

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Evidence-based treatments (EBTs) with a single-disorder focus have improved the potential for youth mental health care, yet may be an imperfect fit to clinical care settings where diagnostic comorbidity and co-occurring problems are commonplace. Most EBTs were developed to treat one diagnosis or problem (or a small homogenous cluster), but most clinically referred youths present with multiple disorders and problems. Three emerging approaches may help address the comorbidity that is so common in treated youths. Conceptually unified treatments target presumed causal and maintaining factors that are shared among more than one disorder or problem area; preliminary open trials and case studies show promising results. Modular protocolscombine the 'practice elements' that commonly appear in separate single-disorder EBTs and repackage theminto coordinated delivery systems; one modular protocol, MATCH, has produced positive findings in a randomized effectiveness trial. Monitoring and Feedback Systems (MFSs) provide real-time data on client progress to inform clinical decision-making, encompassing comorbid and co-occurring problems; onestudyshows beneficial effects in everyday practice with diverse youth problems. All three approaches - conceptually unified, modular, and MFS - can be strengthened by increased research attention to treatmentintegrity, clinician user-appeal, design simplicity, and the infrastructure necessary for successful implementation.