Abstract
Combining antidepressants was more effective than antidepressant monotherapy in the treatment of adults with acute depression, a systematic review and meta‐analysis encompassing 39 trials has found. Combinations of a monoamine reuptake inhibitor and a presynaptic alpha‐2 adrenoreceptor antagonist showed the most promising results among the studied combination treatments. Results of the review and meta‐analysis were published online February 16, 2022, in JAMA Psychiatry.
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