Abstract
Atopic Dermatitis (AD) is probably the most common type of eczema. The quality of life assessment reveals a number of negative consequences for patients with AD and their families. AD is associated with high levels of stress, stigma, social withdrawal, anxiety, depression, and even suicide ideation. Atopic dermatitis is a multisystem inflammatory disease with a multifactorial, and still controversial etiology. Complex interactions between genetic, psychoneuroimmune and endocrine factors, microbiome, exposome and environment, mental and social factors, diet and lifestyle are proposed. AD is difficult to treat, has a chronic course with peaks of exacerbation and pronounced manifestation of mental factors. Such complexity requires deeper understanding of mechanisms behind AD. We consider a possible psychogenic component in diseaseexacerbation, andoffera different point of view onrelationships of human body with the colonizing microbiomein the context of AD etiology and pathogenesis. These relationships are interpreted in evolutionary terms in an attempt to shed some light on mechanisms of chronic and pathological skin processes. Keywords: Atopic Dermatitis; Microbiome; Exposome;Obsessive- Compulsive Disorder
Highlights
Atopic dermatitis is probably the most common type of eczema
It affects a total of about 30% of children and adults [1,2].Its external symptoms are characterized by sebostatic, ichthyosiform and xerotic skin
Atopic dermatitis is examined in a wide range of research areas due to its strong impact on psychosocial functioning, and on subjective quality of life
Summary
Atopic dermatitis is probably the most common type of eczema. It affects a total of about 30% of children and adults [1,2].Its external symptoms are characterized by sebostatic, ichthyosiform and xerotic skin. Relationship of human organism and its colonizing microbiome should be reviewedto assess mechanisms that are responsible for forming a healthy barrier that separates organism from exposome.
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