Abstract
SummaryBackgroundAccumulating evidence, outlined in this review, at last provides some elucidation of the orgin of gastrointestinal epithelial tumours.MethodsNew techniques, such as following the process of crypt or gastric gland purification following mutation in genes encoded by the mitochondrial genome, have shown that mutations spead within the proliferative unit, either gastric gland or intestinal crypt, by clonal purification or monoclonal conversion. Spreading otside the crypt or gland then takes place by fission.ResultsFuture research should focus on the mecanisim by which mutated stem cells colonize crypts, and on the mechanisms of crypt fission itself.
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