Review Article-A Concise Overview on Recent Advances in Pharmaceutical Aerosols and Their Commercial Application

Abstract

For the treatment of various pulmonary disease such as asthma, chronic abstractive disease, pneumonia, bronchitis, and cystic fibrosis, localized drug delivery to the respiratory system has shown to be an increasingly effective and crucial approach. The global market for respiratory inhaler device is being propelled in large part by the increasing prevalence of respiratory disease. The main objective of this article is to present various aspect of pharmaceutical aerosol, including their various types, components, in-process and finished product quality control, and their commercial applications. Aerosol also known as a pressurized device work by continuously or metered applying a small mist spray to activate a suitable valve system. Aerosol is not only used for the treatment of asthma and chronic obstructive pulmonary disease but also used to treat a wide range of other conditions including diabetes, cancer, angina pectoris, bone disorder, and acute lung injury, bone disorders, and tuberculosis. The therapeutic efficacy of pharmaceutical aerosol is affected by wide range of factors, such as the types and characteristics of propellant, active ingredient, container, valve, actuator, spray pattern, valve crimping efficiency, and aerosol particle size. Key words: - Aerosol, types, metered dose inhaler, dry powder inhaler, nebulizers, commercial applications.