Abstract
This review aimed to inform about the magnetic nanoparticle functionalization and solid magnetic phase extraction application to separate analytes in various types of samples. The review was conducted by analyzing several articles published in 2010 until 2021 obtained through search engines, such as Science Direct, Google Scholar and PubMed, using the keyword “magnetic phase extraction” and “magnetic nanoparticle”. The magnetic nanoparticle can be functionalized with organic, inorganic, and metal-organic framework compounds to obtain good selectivity and extraction capability. The Magnetic Solid Phase Extraction (MSPE) can be applied to separate analytes in biological, food, environmental samples. The MSPE can be used in various biological, food, and environmental samples resulting in high enrichment factor value, good recovery, and the magnetic adsorbent has excellent reusability.
Highlights
Sample preparation is one of the essential steps in complex matrix analysis
It is necessary to pay attention to the pH used in the extraction process
The Magnetic Solid Phase Extraction (MSPE) can be used in various biological, food, and environmental samples resulting in high enrichment factor value, good recovery, and the magnetic adsorbent has excellent reusability
Summary
Sample preparation is one of the essential steps in complex matrix analysis. One of the steps in sample preparation is the extraction process. Solid-phase extraction (SPE) is one of the extraction methods that has the advantage of simultaneous or selective to a substance because different adsorbents interact with different substances [2]. This SPE technique has several disadvantages due to adsorbent packings, such as blockage of the sorbent and high pressure. One method that can be used to overcome this problem is to use the Magnetic Solid Phase Extraction (MSPE) technique [3]
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