Abstract

This pre-print offers a novel diagnostic platform that uses off-the-shelf glucometers to detect SARS-CoV-2 antigens in saliva. The current manuscript offers rigorous validation of the diagnostic technology, but further experiments should be performed before clinical use.

Highlights

  • Review: The paper describes the sensitive and specific qualitative detection of SARS-CoV-2 salivary antigen using off-shelf commercial glucometer as a portable readout

  • The transduction strategy from COVID-19 antigen to glucose directly refers from the method initially reported in the Nat

  • Highlights: The paper contains highlights in multiple aspects. It focuses on the most concerned COVID-19 pandemic that is on extremely urgent requirement to improve detection speed, accuracy, and especially, portability

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Summary

Introduction

Review 3: "Hitting the diagnostic sweet spot: Point-of-care SARS-CoV-2 salivary antigen testing with an o -the-shelf glucometer The main study claims are generally justified by its methods and data. The results and conclusions are likely to be similar to the hypothetical ideal study. There are some minor caveats or limitations, but they would/do not change the major claims of the study.

Results
Conclusion

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