Abstract

This preprint offers a retrospective analysis evaluating correlations between SARS-CoV-2 Variants of Concern and disease severity in children. The study finds that neither alpha or delta variants were associated with severe COVID-19 symptoms. Reviewers deemed the study reliable.

Highlights

  • Review 2: "Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children:

  • Review: In this interesting paper, the authors quantify the risk of variants of concern of SARSCoV-2 for severe Covid-19 in nearly 500 children and adolescents, testing the severity with different variables

  • The authors provide data revealing an increase in the risk of hospitalization, respiratory support, and severe disease for gamma variant compared to no variants of concern – but not for alpha and delta

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Summary

Introduction

Review 2: "Severity of Illness Caused by Severe Acute Respiratory Syndrome Coronavirus 2 Variants of Concern in Children: A Single-Center Retrospective Cohort Study The main study claims are generally justified by its methods and data. The study provides sufficient strength of evidence on its own that its main claims should be considered actionable, with some room for future revision.

Results
Conclusion
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